[PDF][PDF] The Role of Inflammation, Telomere Length and Hippocampal Neurogenesis in the Aetiology and Treatment of Psychiatric Disorders

A Palmos - 2020 - kclpure.kcl.ac.uk
Psychiatric disorders such as major depressive disorder, bipolar disorder and schizophrenia
are a tremendous burden on society, globally accounting for more than 30% of years lived …

[HTML][HTML] Telomere length and human hippocampal neurogenesis

AB Palmos, RRR Duarte, DM Smeeth… - …, 2020 - nature.com
Short telomere length is a risk factor for age-related disease, but it is also associated with
reduced hippocampal volumes, age-related cognitive decline and psychiatric disorder risk …

[PDF][PDF] The genomic clock: exploring the relationship between telomere length and mental disorders

Y Jiang, ZQ Du, HH Zhu - Psychosom Med Res, 2023 - tmrjournals.com
In the realm of neurology and cellular aging, a compelling nexus is being drawn between
mental disorders and the intricate clockwork of our genetic machinery, specifically telomere …

[HTML][HTML] Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder

F Mamdani, B Rollins, L Morgan, RM Myers… - Translational …, 2015 - nature.com
Stress can be a predisposing factor to psychiatric disorders and has been associated with
decreased neurogenesis and reduced hippocampal volume especially in depression …

Adult hippocampal neurogenesis in major depressive disorder and Alzheimer's disease

T Berger, H Lee, AH Young, D Aarsland… - Trends in molecular …, 2020 - cell.com
Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …

Adult neurogenesis, mental health, and mental illness: hope or hype?

AJ Eisch, HA Cameron, JM Encinas… - Journal of …, 2008 - Soc Neuroscience
Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the
devastating symptoms and consequences of neuropsychiatric disorders such as addiction …

[HTML][HTML] Immediate early genes anchor a biological pathway of proteins required for memory formation, long-term depression and risk for schizophrenia

KK Marballi, AL Gallitano - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
While the causes of myriad medical and infectious illnesses have been identified, the
etiologies of neuropsychiatric illnesses remain elusive. This is due to two major obstacles …

Why has adult hippocampal neurogenesis had so little impact on psychiatry?

KY Liu, R Howard - The British Journal of Psychiatry, 2018 - cambridge.org
Hippocampal neurogenesis continues throughout adult life and potentially plays a crucial
role in mood and cognitive disorders. We summarise the preclinical insights and potential …

Mechanisms of action of telomere-related genes and telomere length-related proteins in relation to psychiatric disorders: A multi-method Mendelian Randomization …

J Shen, Y Feng, H Yan - Available at SSRN 4527773, 2023 - papers.ssrn.com
Background: Psychiatric disorders (PD) refer to disorders that affect individual thinking,
emotional regulation, and behavior. Notably, PD are associated with factors such as genes …

Adult neurogenesis and psychiatric disorders

E Kang, Z Wen, H Song… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Psychiatric disorders continue to be among the most challenging disorders to diagnose and
treat because there is no single genetic or anatomical locus that is causative for the disease …