The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …

Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it
downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is …

Defining functional domains and amino acid residues in G protein coupled receptors
(GPCRs) represent an important way to improve rational drug design for this major class of …

Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as
CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses …

In central neurons, the cell-surface distribution of cannabinoid receptor subtype-1 (CB1) is
highly polarized toward axons and is associated with synaptic terminals, in which it is well …

The identification and cloning of the two major cannabinoid (CB1 and CB2) receptors
together with the discovery of their endogenous ligands in the late 80s and early 90s …

The cannabinoid 1 receptor (CB1R) is one of the most abundant G protein–coupled
receptors (GPCRs) in the central nervous system, with key roles during neurotransmitter …

The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …

The majority of G‐protein‐coupled receptors (GPCRs) function at the cell surface, where
they are activated by their ligands present in the extracellular milieu. Interestingly, type I …

Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …