Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis

M Jin, R Günther, K Akgün, A Hermann, T Ziemssen - Scientific reports, 2020 - nature.com
Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS),
but only limited data are available on systematic peripheral and central immune cell profiles …

T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis

M Saresella, F Piancone, P Tortorella, I Marventano… - Clinical …, 2013 - Elsevier
MS (multiple sclerosis) and ALS (amyotrophic lateral sclerosis) differ in important respects,
but common pathogenic features seem to be shared in these two diseases. To shed light on …

Alterations of T cell subsets in ALS: a systemic immune activation?

M Rentzos, E Evangelopoulos, E Sereti… - Acta Neurologica …, 2012 - Wiley Online Library
Rentzos M, Evangelopoulos E, Sereti E, Zouvelou V, Marmara S, Alexakis T, Evdokimidis I.
Alterations of T cell subsets in amyotrophic lateral sclerosis: a systemic immune activation …

Plasma inflammatory cytokines are elevated in ALS

R Tortelli, C Zecca, M Piccininni… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which leads
to death in a median time of 2–3 years. Inflammation has been claimed important to the ALS …

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

MP Gustafson, NP Staff, S Bornschlegl, GW Butler… - PloS one, 2017 - journals.plos.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a median
lifespan of 2–3 years after diagnosis. There are few meaningful treatments that alter …

Peripheral and central nervous system immune response crosstalk in amyotrophic lateral sclerosis

Z Liu, X Cheng, S Zhong, X Zhang, C Liu… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
muscle weakness due to the degeneration of the upper and lower motor neurons …

Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

Y Hu, C Cao, XY Qin, Y Yu, J Yuan, Y Zhao… - Scientific Reports, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly
understood etiology. Increasing evidence suggest that inflammation may play a critical role …

Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis

BJ Murdock, DE Bender, SR Kashlan… - Neurology …, 2016 - AAN Enterprises
Objective: To elucidate amyotrophic lateral sclerosis (ALS) biomarkers and potential
mechanisms of disease, we measured immune cell populations in whole blood from a large …

Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate

N Shi, Y Kawano, T Tateishi, H Kikuchi… - Journal of …, 2007 - Elsevier
We measured the intracellular productions of IFNγ, IL-2, IL-4, IL-13 and TNFα in peripheral
blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 …

Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis

RB McGill, FJ Steyn, ST Ngo, KA Thorpe… - Brain …, 2020 - academic.oup.com
Immunity has emerged as a key player in neurodegenerative diseases such as amyotrophic
lateral sclerosis, with recent studies documenting aberrant immune changes in patients and …