Peripheral proinflammatory Th1/Th17 immune cell shift is linked to disease severity in amyotrophic lateral sclerosis
Neuroinflammation is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS),
but only limited data are available on systematic peripheral and central immune cell profiles …
but only limited data are available on systematic peripheral and central immune cell profiles …
T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis
M Saresella, F Piancone, P Tortorella, I Marventano… - Clinical …, 2013 - Elsevier
MS (multiple sclerosis) and ALS (amyotrophic lateral sclerosis) differ in important respects,
but common pathogenic features seem to be shared in these two diseases. To shed light on …
but common pathogenic features seem to be shared in these two diseases. To shed light on …
Alterations of T cell subsets in ALS: a systemic immune activation?
M Rentzos, E Evangelopoulos, E Sereti… - Acta Neurologica …, 2012 - Wiley Online Library
Rentzos M, Evangelopoulos E, Sereti E, Zouvelou V, Marmara S, Alexakis T, Evdokimidis I.
Alterations of T cell subsets in amyotrophic lateral sclerosis: a systemic immune activation …
Alterations of T cell subsets in amyotrophic lateral sclerosis: a systemic immune activation …
Plasma inflammatory cytokines are elevated in ALS
R Tortelli, C Zecca, M Piccininni… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease which leads
to death in a median time of 2–3 years. Inflammation has been claimed important to the ALS …
to death in a median time of 2–3 years. Inflammation has been claimed important to the ALS …
Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis
MP Gustafson, NP Staff, S Bornschlegl, GW Butler… - PloS one, 2017 - journals.plos.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a median
lifespan of 2–3 years after diagnosis. There are few meaningful treatments that alter …
lifespan of 2–3 years after diagnosis. There are few meaningful treatments that alter …
Peripheral and central nervous system immune response crosstalk in amyotrophic lateral sclerosis
Z Liu, X Cheng, S Zhong, X Zhang, C Liu… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
muscle weakness due to the degeneration of the upper and lower motor neurons …
muscle weakness due to the degeneration of the upper and lower motor neurons …
Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with poorly
understood etiology. Increasing evidence suggest that inflammation may play a critical role …
understood etiology. Increasing evidence suggest that inflammation may play a critical role …
Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis
BJ Murdock, DE Bender, SR Kashlan… - Neurology …, 2016 - AAN Enterprises
Objective: To elucidate amyotrophic lateral sclerosis (ALS) biomarkers and potential
mechanisms of disease, we measured immune cell populations in whole blood from a large …
mechanisms of disease, we measured immune cell populations in whole blood from a large …
Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate
N Shi, Y Kawano, T Tateishi, H Kikuchi… - Journal of …, 2007 - Elsevier
We measured the intracellular productions of IFNγ, IL-2, IL-4, IL-13 and TNFα in peripheral
blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 …
blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 …
Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis
Immunity has emerged as a key player in neurodegenerative diseases such as amyotrophic
lateral sclerosis, with recent studies documenting aberrant immune changes in patients and …
lateral sclerosis, with recent studies documenting aberrant immune changes in patients and …