Synthesis, biological evaluation, and molecular docking of N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl}-benzamide/amide derivatives as xanthine oxidase …
Claisen–Schmidt condensation of 3-formyl-9-methylcarbazole with various amides of 3-
aminoacetophenone afforded N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl} …
aminoacetophenone afforded N-{3-[3-(9-methyl-9H-carbazol-3-yl)-acryloyl]-phenyl} …
Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1, 2, 3-triazole-4, 5-dicarboxylate and (N-benzyl-1H …
This study focused on synthesis various dimethyl N-benzyl-1H-1, 2, 3-triazole-4, 5-
dicarboxylate and (N-benzyl-1H-1, 2, 3-triazole-4, 5-diyl) dimethanol derivatives under the …
dicarboxylate and (N-benzyl-1H-1, 2, 3-triazole-4, 5-diyl) dimethanol derivatives under the …
Design, synthesis, and biological evaluation of 5‐(4‐(pyridin‐4‐yl)‐1H‐1,2,3‐triazol‐1‐yl)benzonitrile derivatives as xanthine oxidase inhibitors
T Zhang, S Li, Y Zhang, Q Wu… - Chemical Biology & Drug …, 2018 - Wiley Online Library
A series of 5‐(4‐(pyridin‐4‐yl)‐1H‐1, 2, 3‐triazol‐1‐yl) benzonitrile derivatives (1a–p) was
designed, synthesized, and identified as xanthine oxidase inhibitors with micromolar level …
designed, synthesized, and identified as xanthine oxidase inhibitors with micromolar level …
Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors
A Shi, L Zhang, H Wang, S Wang, M Yang… - European Journal of …, 2018 - Elsevier
Abstract A series of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives (7a‒c, 8a‒
e, 9a‒e and 10a‒e) as novel xanthine oxidase inhibitors were designed based on …
e, 9a‒e and 10a‒e) as novel xanthine oxidase inhibitors were designed based on …
Thiazole-5-carboxylic acid derivatives as potent xanthine oxidase inhibitors: design, synthesis, in vitro evaluation, and molecular modeling studies
A series of 22 compounds of thiazole-5-carboxylic acid derivatives was rationally designed
and synthesized. All the compounds were characterized by using 1 H and 13 C NMR and …
and synthesized. All the compounds were characterized by using 1 H and 13 C NMR and …
Discovery and biological evaluation of some (1H-1, 2, 3-triazol-4-yl) methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine …
T Zhang, S Li, W Yuan, Q Wu, L Wang, S Yang… - Bioorganic & Medicinal …, 2017 - Elsevier
Abstract A series of (1H-1, 2, 3-triazol-4-yl) methoxybenzaldehyde derivatives containing an
anthraquinone moiety were synthesized and identified as novel xanthine oxidase inhibitors …
anthraquinone moiety were synthesized and identified as novel xanthine oxidase inhibitors …
Design, synthesis and bioevaluation of 3-oxo-6-aryl-2, 3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors
L Zhang, S Wang, M Yang, A Shi, H Wang… - Bioorganic & Medicinal …, 2019 - Elsevier
In view of expanding the structure activity relationship of xanthine oxidase inhibitors, a series
of 3-oxo-6-aryl-2, 3-dihydropyridazine-4-carbohydrazide/carboxylic acid derivatives were …
of 3-oxo-6-aryl-2, 3-dihydropyridazine-4-carbohydrazide/carboxylic acid derivatives were …
Design, synthesis and structure-activity relationship of N-phenyl aromatic amide derivatives as novel xanthine oxidase inhibitors
S Hu, T Zhang, Z Wang, E Xu, Q Wang, X Zhang… - Bioorganic …, 2023 - Elsevier
Our previous studies suggested that N-phenyl aromatic amides are a class of promising
xanthine oxidase (XO) inhibitor chemotypes. In this effort, several series of N-phenyl …
xanthine oxidase (XO) inhibitor chemotypes. In this effort, several series of N-phenyl …
Synthesis, screening and docking of fused pyrano [3, 2-d] pyrimidine derivatives as xanthine oxidase inhibitor
M Kaur, A Kaur, S Mankotia, H Singh, A Singh… - European Journal of …, 2017 - Elsevier
In view of developing effective xanthine oxidase (XO) enzyme inhibitors, a series of 100
pyrano [3, 2-d] pyrimidine derivatives was synthesized and evaluated for its in vitro XO …
pyrano [3, 2-d] pyrimidine derivatives was synthesized and evaluated for its in vitro XO …
Synthesis and xanthine oxidase inhibitory activity of 5, 6-dihydropyrazolo/pyrazolo [1, 5-c] quinazoline derivatives
Abstract Some 5, 6-dihydropyrazolo/pyrazolo [1, 5-c] quinazoline derivatives were rationally
designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the …
designed, synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the …
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