Permanent hearing loss is one of cisplatin's adverse effects, affecting 30–60% of cancer
patients treated with that drug. Our research group recently identified resident mast cells in …

Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted
decrease in quality of life. Identification of early cisplatin-induced cochlear damage would …

Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss.
Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation …

Cisplatin, a highly effective chemotherapeutic drug for various human cancers, induces
irreversible sensorineural hearing loss as a side effect. Currently there are no highly …

Cisplatin is a highly effective anti-tumor drug that is often used to treat a variety of cancers,
such as ovarian, cervical, and brain cancers. However, cisplatin can cause serious side …

Results The mice exhibited substantial hearing loss after noise and cisplatin exposure.
Additionally, more TUNEL positive cells were observed in the mice after noise and cisplatin …

In recent years, molecular biology and biochemistry have been a focus of studies on the
ototoxic side effects of cisplatin. In this paper, the application of cisplatin for 4 h and 72 h was …

Abstract Objectives/Hypothesis Cisplatin induces adverse effects such as ototoxicity and
nephrotoxicity. Unexplained hearing improvement in sudden deafness and fluctuating …

Inner ear macrophages play a vital role in cochlear homeostasis. Recent studies have
demonstrated the existence of macrophages at different sites of the cochlea, with increased …

Aims: Ototoxicity is one of the main side effects of the chemotherapeutic agent Cisplatin
CDDP. CDDP ototoxicity is caused by damage of the organ of Corti, spiral ganglion cells or …