Background Increasing evidence suggests that youth with Major Depressive Disorder (MDD)
exhibit early indicators of cardiovascular disease. A leading hypothesized mechanism of this …

Background Low-grade inflammation is associated with depression, but studies of specific
symptoms are relatively scarce. Association between inflammatory markers and specific …

Inflammation has been implicated in depressive symptoms, but few studies use longitudinal
designs with adolescents. Furthermore, the extant literature has yielded inconsistent results …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

BACKGROUND: There is mounting interest in the hypothesis that inflammation contributes
to the pathogenesis of depression and underlies depressed patients' vulnerability to …

Objective: Meta-analytic evidence shows alterations of peripheral inflammatory cytokines in
adults with depressive disorders. By contrast, no evidence synthesis on alterations of …

Objective: To evaluate the relationship and identify support for pathways linking
inflammatory processes with depression and suicide in children and adolescents. Data …

Background While cytokines have been implicated in the pathophysiology of depression in
adults, the potential role in younger age groups such as adolescents is less clear. This …

Background Stress during early childhood, for example as a result of maltreatment, can
predict inflammation in adulthood. The association of depression with inflammation and …

Context The association between depression and inflammation is inconsistent across
research samples. Objective To test whether a history of childhood maltreatment could …