Aggregated amyloid β-peptide (Aβ) in small oligomeric forms inside the brain causes
synaptic function disruption and the development of Alzheimer's disease (AD). Histidine is …

Amyloid-beta protein (Aβ) accumulation in the brain, which is influenced by several factors,
is a hallmark of Alzheimer's disease (AD). Despite the important role of histidine in …

As the intrinsic origin of the hypothesis for β-amyloid (Aβ) from Alzheimer's disease, histidine
behaviors were found to play a crucial role in Aβ aggregation. To investigate the histidine …

The self-assembly of amyloid-β (Aβ) peptides into senile plaques in the brain is a hallmark of
Alzheimer's disease (AD) pathology. Mutation and histidine tautomerism are considered …

The intrinsic origin of amyloid aggregation has been pursued as a new pathogenesis for
Alzheimer's disease (AD). The aggregation mechanisms influenced by histidine tautomerism …

Histidine state (deprotonated, neutral, and protonated) is considered an important factor
influencing the structural properties and aggregation mechanisms in amyloid β-peptides …

Mutation is considered an important factor in the accumulation of amyloid-β (Aβ), which is a
hallmark of Alzheimer's disease (AD). A2V Aβ40 shows a higher aggregation tendency; …

It is known that oligomers of amyloid-β (Aβ) peptide are associated with Alzheimer's disease.
Aβ has two isoforms: Aβ40 and Aβ42. Although the difference between Aβ40 and Aβ42 is …

Tautomeric state of histidine is one of the factors that influence the structural and
aggregation properties of amyloid β (Aβ)-peptide in neutral state. It is worth it to uncover the …

Hundreds of millions of people around the world have been affected by Type 2 diabetes
(T2D) which is a metabolic disorder. Clinical research has revealed T2D as a possible risk …