Abstract SARS-CoV-2 can re-structure chromatin organization and alter the epigenomic
landscape of the host genome, but the mechanisms that produce such changes remain …

Some viruses restructure host chromatin, influencing gene expression, with implications for
disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is …

Emergence of new viral agents is driven by evolution of interactions between viral proteins
and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV …

SARS-CoV-2 infection triggers profound and variable immune responses in human hosts.
Chromatin remodeling has been observed in individuals severely ill or convalescing with …

Mammalian chromosomes undergo varying degrees of compression to form three‐
dimensional genome structures. These three‐dimensional structures undergo dynamic and …

Classical observations have long suggested there is a link between 3D gene structure and
transcription–. However, due to the many factors regulating gene expression, and to the …

Summary Coronavirus disease 2019 (COVID-19) remains a significant public health threat
due to the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants …

Identifying human proteins that interact with SARS-CoV-2 genome is important to
understand its replication and to identify therapeutic strategies. Recent studies have …

Understanding the mechanisms underlying the complex 3D architecture of mammalian
genomes poses, at a more fundamental level, the problem of how two or multiple genomic …

Cell–cell interactions (CCI) play significant roles in manipulating biological functions of cells.
Analyzing the differences in CCI between healthy and diseased conditions of a biological …