CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

F Taube, JA Georgi, M Kramer, S Stasik… - Blood, The Journal …, 2022 - ashpublications.org
Biallelic mutations of the CEBPA gene (CEBPA bi) define a distinct entity associated with
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely …

BJ Wouters, B Löwenberg… - Blood, The Journal …, 2009 - ashpublications.org
Mutations in CCAAT/enhancer binding protein α (CEBPA) are seen in 5% to 14% of acute
myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most …

Prognostic impact of CEBPA bZIP domain mutation in acute myeloid leukemia

S Wakita, M Sakaguchi, I Oh, S Kako, T Toya… - Blood …, 2022 - ashpublications.org
Mutations of CCAAT/enhancer–binding protein alpha (CEBPA mu) are found in 10% to 15%
of de novo acute myeloid leukemia (AML) cases. Double-mutated CEBPA (CEBPA dm) is …

CEBPA-bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children's Oncology Group

K Tarlock, AJ Lamble, YC Wang… - Blood, The Journal …, 2021 - ashpublications.org
Biallelic CEBPA mutations are associated with favorable outcomes in acute myeloid
leukemia (AML). We evaluated the clinical and biologic implications of CEBPA-basic leucine …

Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical …

A Dufour, F Schneider, KH Metzeler… - Journal of clinical …, 2010 - ascopubs.org
Purpose CEBPA mutations are found as either biallelic (bi CEBPA) or monoallelic (mo
CEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic …

Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

PA Ho, TA Alonzo, RB Gerbing, J Pollard… - Blood, The Journal …, 2009 - ashpublications.org
CEBPA mutations have been associated with improved outcome in adult acute myeloid
leukemia (AML). We evaluated the prevalence and prognostic significance of CEBPA …

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further …

E Taskesen, L Bullinger, A Corbacioglu… - Blood, The Journal …, 2011 - ashpublications.org
We evaluated concurrent gene mutations, clinical outcome, and gene expression signatures
of CCAAT/enhancer binding protein alpha (CEBPA) double mutations (CEBPA dm) versus …

[HTML][HTML] CEBPA–double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

F Mannelli, V Ponziani, S Bencini, MI Bonetti… - …, 2017 - ncbi.nlm.nih.gov
Mutations in CCAAT/enhancer binding protein α (CEBPA) occur in 5–10% of cases of acute
myeloid leukemia. CEBPA-double-mutated cases usually bear biallelic N-and C-terminal …

Somatic CEBPA Mutations Are a Frequent Second Event in Families With Germline CEBPA Mutations and Familial Acute Myeloid Leukemia

T Pabst, M Eyholzer, S Haefliger, J Schardt… - Journal of Clinical …, 2008 - ascopubs.org
Purpose The transcription factor CCAAT/enhancer binding protein-α (CEBPA) is crucial for
normal myeloid differentiation. Mutations in the CEBPA gene are found in subsets of patients …

Characterization of CEBPA Mutations in Acute Myeloid Leukemia: Most Patients with CEBPA Mutations Have Biallelic Mutations and Show a Distinct …

LI Lin, CY Chen, DT Lin, W Tsay, JL Tang, YC Yeh… - Clinical cancer …, 2005 - AACR
Purpose: The transcription factor CCAAT/enhancer binding protein α, encoded by the
CEBPA, is crucial for the differentiation of immature granulocytes. Mutation of the CEBPA …