A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)–
induced signals. We show here that mice doubly deficient in either A20 and TNF or A20 and …

Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonical ubiquitination of TNF
receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and …

NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour
necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity …

A20 negatively regulates inflammation by inhibiting the nuclear factor κB (NF-κB)
transcription factor in the tumor necrosis factor–receptor (TNFR) and Toll-like receptor (TLR) …

Muramyl dipeptide (MDP), a product of bacterial cell-wall peptidoglycan, activates innate
immune cells by stimulating nucleotide-binding oligomerization domain containing 2 …

Protein ubiquitination plays a critical role in Toll-like receptor (TLR) signaling and innate
immunity. Although several E3 ubiquitin ligases have been identified downstream of TLRs …

Nuclear factor κB (NF-κB) activation in tumor necrosis factor, interleukin-1, and Toll-like
receptor pathways requires Lys63-linked nondegradative polyubiquitination. A20 is a …

A20 has been suggested to limit NF‐κB activation by removing regulatory ubiquitin chains
from ubiquitinated substrates. A20 is a ubiquitin‐editing enzyme that removes K 63‐linked …

The non-canonical NF-κB pathway forms a major arm of NF-κB signalling that mediates
important biological functions, including lymphoid organogenesis, B-lymphocyte function …

The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour
growth factor‐beta (TGF‐β) signalling. RNF11 has been proposed to regulate TGF‐β …