In recent years, sphingolipids have emerged as critical molecules in the regulation of
microbial pathogenesis. In fungi, the synthesis of complex sphingolipids is important for the …

In this work, we biochemically characterized inositol phosphosphingolipid-phospholipase C
(Isc1) from the pathogenic fungus Cryptococcus neoformans. Unlike Isc1 from other fungi …

Cryptococcus neoformans is a human fungal pathogen that often causes lung and brain
infections in immunocompromised patients, with a high fatality rate. Our previous results …

The key host cellular pathway (s) necessary to control the infection caused by inhalation of
the environmental fungal pathogen Cryptococcus neoformans are still largely unknown …

Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

Cryptococcus neoformans is a facultative intracellular pathogen, which can replicate in the
acidic environment inside phagolysosomes. Deletion of the enzyme inositol …

In previous studies we showed that the replication of Cryptococcus neoformans in the lung
environment is controlled by the glucosylceramide (GlcCer) synthase gene (GCS1), which …

Cryptococcus neoformans is a leading cause of life-threatening fungal infection in
immunocompromised patients. Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus …

ABSTRACT Phospholipase C (PLC) of Cryptococcus neoformans (Cn Plc1) is crucial for
virulence of this fungal pathogen. To investigate the mechanism of CnPlc1-mediated …

Fungal infections pose a significant risk for the increasing population of individuals who are
immunocompromised. Phagocytes play an important role in immune defense against fungal …