2D Catalytic Niobium Carbide MXenzyme for Ameliorating Noise‐Induced Hearing Loss

B Xu, Q Jiang, Y Huang, K Xu, W Feng… - Advanced Functional …, 2024 - Wiley Online Library
Noise‐induced hearing loss (NIHL), a prevalent sensory disability affecting a majority of the
global population, is dominantly induced by mitochondrial dysfunction and oxidative stress …

Application of Self-assembly Palladium Single-atom Nanozyme over Polyoxometalates in Protection against Neomycin-induced Hearing Loss by Inhibiting Ferroptosis

Q Huo, C Chen, J Liao, Q Zeng, G Nie, B Zhang - Biomaterials, 2024 - Elsevier
Deafness mainly results from irreversible impairment of hair cells (HCs), which may relate to
oxidative stress, yet therapeutical solutions is lacked due to limited understanding on the …

Mitochondrial redox system: A key target of antioxidant therapy to prevent acquired sensorineural hearing loss

JI Baek, YR Kim, KY Lee, UK Kim - Frontiers in Pharmacology, 2023 - frontiersin.org
Noise (noise-induced hearing loss), and ototoxic drugs (drug-induced ototoxicity), and aging
(age-related hearing loss) are the major environmental factors that lead to acquired …

Superoxide dismutase@ zeolite imidazolate framework-8 attenuates noise-induced hearing loss in rats

Y Zhang, Q Li, C Han, F Geng, S Zhang, Y Qu… - Frontiers in …, 2022 - frontiersin.org
Reactive oxygen species (ROS) and inflammation have been considered major contributors
to noise-induced hearing loss (NIHL) that constituted a public health threat worldwide …

ROS scavenging Mn 3 O 4 nanozymes for in vivo anti-inflammation

J Yao, Y Cheng, M Zhou, S Zhao, S Lin, X Wang… - Chemical …, 2018 - pubs.rsc.org
Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases,
including cardiovascular disease and cancer. Though highly efficient natural ROS …

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

W Feng, X Han, H Hu, M Chang, L Ding… - Nature …, 2021 - nature.com
Reactive oxygen species (ROS) are generated and consumed in living organism for normal
metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been …

Approaches to mitigate mitochondrial dysfunction in sensorineural hearing loss

MN Okur, HR Djalilian - Annals of Biomedical Engineering, 2022 - Springer
Mitochondria are highly dynamic multifaceted organelles with various functions including
cellular energy metabolism, reactive oxygen species (ROS) generation, calcium …

Incorporation of a biocompatible nanozyme in cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model

A Adhikari, S Mondal, M Das, P Biswas… - Advanced …, 2021 - Wiley Online Library
The potentiality of nano‐enzymes in therapeutic use has directed contemporary research to
develop a substitute for natural enzymes, which are suffering from several disadvantages …

Engineering core–shell chromium nanozymes with inflammation-suppressing, ROS-scavenging and antibacterial properties for pulpitis treatment

F Xie, C Zhu, L Gong, N Zhu, Q Ma, Y Yang, X Zhao… - Nanoscale, 2023 - pubs.rsc.org
Oral diseases are usually caused by inflammation and bacterial infection. Reactive oxygen
species (ROS), which come from both autologous inflammation tissue and bacterial …

Nitric oxide protects against cochlear hair cell damage and noise-induced hearing loss through glucose metabolic reprogramming

H Yang, Y Zhu, Y Ye, J Guan, X Min, H Xiong - Free Radical Biology and …, 2022 - Elsevier
Nitric oxide (NO) is critically involved in the regulation of a wide variety of physiological and
pathophysiological processes. However, the role of NO in the pathogenesis of noise …