Objective To assess if a coding variant in the gene encoding transient receptor potential
cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful …

Abstract Background Substance P (SP) is a pain‐and inflammation‐related neuropeptide
which preferentially binds to the neurokinin receptor 1 (NK 1). SP and NK 1 receptors have …

Objective In these studies, we examined the association of single nucleotide polymorphisms
(SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis …

Objective The aim of the current study was to investigate whether genetic variation in genes
across the serotoninergic system is associated with chronic widespread pain (CWP) and the …

Objectives Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic
antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target …

Recent studies have suggested that polymorphisms in toll‐like receptor 9 (TLR‐9), an
endosomal TLR, are associated with knee osteoarthritis (OA). TLR‐3,‐7, and‐8 are also …

Objective. Researchers continue to gather evidence that transient receptor potential
vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is …

Background and objectives Chronic widespread musculoskeletal pain (CWP) is a symptom
of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable …

Objective To assess the genetic association of pain in patients with knee osteoarthritis (OA)
and those with multiple regional pain with the R1150W variant in the α‐subunit of the …

Objectives To determine whether genetic variation within genes related to the Toll-like
receptor, inflammasome and interferon-γ pathways contributes to the differences in …