The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …

The presence of cytosolic double-stranded DNA molecules can trigger multiple innate
immune signalling pathways which converge on the activation of an ER-resident innate …

How the cell recognizes cytosolic DNA including DNA-based microbes to trigger host-
defense-related gene activation remains to be fully resolved. Here, we demonstrate that …

Stimulator of interferon genes (STING) was initially described as a sensor of intracellular
bacterial and viral DNA and a promising adjuvant target in innate immune cells; more …

Highlights•Self-DNA activates STING regulated autoinflammatory responses.•Nucleases
such as DNaseII and III prevent inflammation by degrading STING activators.•Gain of …

Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it
is only in the past five years that the molecular basis of DNA sensing by the innate immune …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

Spontaneous T cell responses against tumors occur frequently and have prognostic value in
patients. The mechanism of innate immune sensing of immunogenic tumors leading to …

The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-
STING signaling and induces the production of type I interferons, which play critical roles in …

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress
signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS …