SARS-CoV-2, the coronavirus strain that initiated the COVID-19 pandemic, and its
subsequent variants present challenges to vaccine development and treatment. As the …

SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world
causing a deadly pandemic with tremendous social and economic costs. Healthcare …

Abstract SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …

The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To
date, there are limited therapeutic options available to fight this disease. Here we examined …

SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-
December, 2020. Although great progress has been made in the development of effective …

The outbreak of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus
represents a significant threat to global health, with an estimated R0 of 2.24–4.08 and a …

SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …

Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain
and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 …

The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines
and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The …

Background: The coronavirus disease 2019 pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 210 million …