Drug-metabolizing cytochrome P450 (CYPs) enzymes are expressed in the liver, as well as
in extrahepatic tissues such as the brain. Here we show for the first time that drug …

Cytochrome P450 enzymes (CYPs) metabolize many drugs that act on the central nervous
system (CNS), such as antidepressants and antipsychotics; drugs of abuse; endogenous …

Risk for side-effects after acute (eg parkinsonism) or chronic (eg tardive dyskinesia)
treatment with antipsychotics, including haloperidol, varies substantially among people …

CYP2B is a drug-metabolizing enzyme expressed in the liver and brain that metabolizes a
variety of centrally acting drugs (eg propofol, bupropion and nicotine), endogenous …

The functional role of cytochrome P450 (CYP) enzymes in the brain is an exciting and
evolving field of research. CYPs are present and active in the brain, with heterogeneous …

Individuals vary in their response to centrally acting drugs, and this is not always predicted
by drug plasma levels. Central metabolism by brain cytochromes P450 (CYPs) may …

Cytochrome P450 (CYP) 2D6, an enzyme found in the liver and the brain, is involved in the
metabolism of numerous centrally acting drugs (eg antidepressants, neuroleptics, opiates) …

Cytochrome P450 (CYP) enzymes in the brain may have a role in the activation or
inactivation of centrally acting drugs, in the metabolism of endogenous compounds, and in …

The response to centrally acting drugs is highly variable between individuals and does not
always correlate with plasma drug levels. Drug-metabolizing CYP enzymes in the brain may …

Brain expression of cytochromes P450 2B6, 2D6 and 2E1 is higher in smokers, and is
induced by nicotine in animals. These enzymes can metabolize many of the neurotoxins …