Perineuronal nets: plasticity, protection, and therapeutic potential

AC Reichelt, DJ Hare, TJ Bussey, LM Saksida - Trends in neurosciences, 2019 - cell.com
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

Regulation of perineuronal nets in the adult cortex by the activity of the cortical network

G Devienne, S Picaud, I Cohen, J Piquet… - Journal of …, 2021 - Soc Neuroscience
Perineuronal net (PNN) accumulation around parvalbumin-expressing (PV) inhibitory
interneurons marks the closure of critical periods of high plasticity, whereas PNN removal …

The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

Removal of perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma activity

KK Lensjø, ME Lepperød, G Dick… - Journal of …, 2017 - Soc Neuroscience
Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of …

Perineuronal nets suppress plasticity of excitatory synapses on CA2 pyramidal neurons

KE Carstens, ML Phillips, L Pozzo-Miller… - Journal of …, 2016 - Soc Neuroscience
Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum
rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets …

[HTML][HTML] Impact of perineuronal nets on electrophysiology of parvalbumin interneurons, principal neurons, and brain oscillations: a review

JC Wingert, BA Sorg - Frontiers in synaptic neuroscience, 2021 - frontiersin.org
Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

[HTML][HTML] The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders

TH Wen, DK Binder, IM Ethell… - Frontiers in molecular …, 2018 - frontiersin.org
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …

Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons

G Faini, A Aguirre, S Landi, D Lamers, T Pizzorusso… - Elife, 2018 - elifesciences.org
In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of
perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

[PDF][PDF] A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain

L Lupori, V Totaro, S Cornuti, L Ciampi, F Carrara… - Cell Reports, 2023 - cell.com
Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various
forms of plasticity and clinical conditions. However, our understanding of the PNN role in …