ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by
small vessel alterations and progressive fibrosis of the skin and internal organs. The …

Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

A unique feature of systemic sclerosis (SSc) that distinguishes it from other fibrotic disorders
is that autoimmunity and vasculopathy characteristically precede fibrosis. Moreover, fibrosis …

Cytokines and growth factors are key regulators of immune activation, vascular alteration
and excessive production of extracellular matrix which are hallmark events in the …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Autoimmune and inflammatory phenomena are characteristically present in systemic
sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition …

Systemic sclerosis (SSc) is characterized by vascular alterations, activation of the immune
system and tissue fibrosis. Vascular insufficiency manifests early in the disease, and …

Systemic sclerosis (SSc) is a multisystem autoimmune and vascular disease resulting in
fibrosis of various organs with unknown etiology. Accumulating evidence suggests that a …