Abstract TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …

TDP-43 aggregates are the neurohistological landmark of diseases like amyotrophic lateral
sclerosis and frontotemporal dementia. Their role in the pathogenesis of these conditions is …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients
with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS) …

Since the discovery that 43 kDa TAR DNA binding protein (TDP-43) is involved in
neurodegeneration, studies of this protein have focused on the global effects of TDP-43 …

TDP-43 is one of the major components of the neuronal and glial inclusions observed in
several neurodegenerative diseases such as amyotrophic lateral sclerosis and …

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are
evident in the brain and spinal cord of patients that present across a spectrum of …

Protein misfolding is intimately associated with devastating human neurodegenerative
diseases, including Alzheimer's, Huntington's, and Parkinson's. Although disparate in their …

Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively
unknown nuclear protein implicated in transcriptional repression and splicing. Since 2006 …