The impressive relief from restless legs syndrome (RLS) symptoms provided by levodopa
treatment indicates RLS is caused by a dopaminergic abnormality. But similar and more …

Evidence for tissue iron deficiency in restless legs syndrome (RLS) is limited to the
substantia nigra (SN). Using MRI, we assessed T2 values of various brain regions in 6 RLS …

Restless leg syndrome (RLS) is a sensorimotor disorder. Clinical studies have implicated
the dopaminergic system in RLS, while others have suggested that it is associated with …

Iron deficiency may exacerbate symptoms in the Restless Legs Syndrome (RLS). We
investigated the effect of intravenous iron sucrose or placebo on symptoms in patients with …

Background and purpose: The evaluation of the pathophysiology of restless legs syndrome
(RLS) stems largely from recognition of the information provided by both pharmacological …

Brain iron insufficiency in the restless legs syndrome (RLS) has been suggested by a prior
CSF study. Using a special MRI measurement (R 2′), the authors assessed regional brain …

Abstract Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of
around 2–5% of the population. Relevant to understanding the possible pathophysiological …

Objective: To assess neuropathology in individuals with restless legs syndrome (RLS).
Methods: A standard neuropathologic evaluation was performed on seven brains from …

Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a
persistent urge to move the legs in the evening that interferes with sleep. Human and animal …

Only in the last three decades, the restless legs syndrome (RLS) has been examined in
randomized controlled trials. The Movement Disorder Society (MDS) commissioned a task …