Nine major HLA class I supertypes account for the vast preponderance of HLA-A and-B polymorphism
Herein, we review the epitope approach to vaccine development, and discuss how
knowledge of HLA supertypes might be used as a tool in the development of such vaccines …
knowledge of HLA supertypes might be used as a tool in the development of such vaccines …
[HTML][HTML] HLA class I supertypes: a revised and updated classification
Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …
T cells, short peptides derived from intracellular processing of proteins. The peptide …
Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs
Recent data suggest that the majority of HLA-A and-B alleles in human populations can be
grouped into four major supertypes, as defined by their broad peptide-binding specificities …
grouped into four major supertypes, as defined by their broad peptide-binding specificities …
Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules
J Sidney, HM Grey, S Southwood, E Celis… - Human immunology, 1996 - Elsevier
An HLA-A3-like supertype (minimally comprised of products from the HLA class I alleles A3,
A11, A31, A∗ 3301, and A∗ 6801) has been defined on the basis of (a) structural similarities …
A11, A31, A∗ 3301, and A∗ 6801) has been defined on the basis of (a) structural similarities …
HLA-B27 and HLA-A2 subtypes: structure, evolution and function
JAL de Castro - Immunology Today, 1989 - Elsevier
Beyond the resolution of tissue typing serology. HLA class I antigens display a certain level
of structural microheterogeneity, that allows their subdivision into subtypes. The structure of …
of structural microheterogeneity, that allows their subdivision into subtypes. The structure of …
HLA supertypes and supermotifs: a functional perspective on HLA polymorphism
A large fraction of HLA class I, and possibly class II, molecules can be classified into
relatively few supertypes, characterized by overlapping peptide-binding repertoires and …
relatively few supertypes, characterized by overlapping peptide-binding repertoires and …
Definition of supertypes for HLA molecules using clustering of specificity matrices
Major histocompatibility complex (MHC) proteins are encoded by extremely polymorphic
genes and play a crucial role in immunity. However, not all genetically different MHC …
genes and play a crucial role in immunity. However, not all genetically different MHC …
Identifiying human MHC supertypes using bioinformatic methods
IA Doytchinova, P Guan, DR Flower - The Journal of Immunology, 2004 - journals.aai.org
Classification of MHC molecules into supertypes in terms of peptide-binding specificities is
an important issue, with direct implications for the development of epitope-based vaccines …
an important issue, with direct implications for the development of epitope-based vaccines …
[HTML][HTML] Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes
LD Barber, B Gillece-Castro, L Percival, X Li… - Current Biology, 1995 - cell.com
Background: Polymorphism among class I molecules of the major histocompatibility complex
(MHC) confers allotypic specificity on the peptides that these molecules bind and present to …
(MHC) confers allotypic specificity on the peptides that these molecules bind and present to …
[引用][C] The Origins of HLA‐A, B, C Polymorphism
Polymorphism of HLA-A, B and C genes determines the repertoire of receptor specificities
expressed by cytolytic CDS T lymphocytes (CTL) and the response of natural killer (NK) …
expressed by cytolytic CDS T lymphocytes (CTL) and the response of natural killer (NK) …