Autoimmune diseases are heterogeneous with regard to prevalence, manifestations, and
pathogenesis. The classification of autoimmune diseases has varied over time. Here, we …

Monogenic autoimmune syndromes provide a rare yet powerful glimpse into the
fundamental mechanisms of immunologic tolerance. Such syndromes reveal not only the …

Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-
constituents of the body. The fully updated third edition of Autoantibodies is an in-depth …

The critical function of the immune system is to discriminate self from non-self. Tolerance
against self-antigens is a highly regulated process and, in order to maintain it, the immune …

There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

Autoantibodies are a hallmark of both autoimmune disease and cancer, but they also occur
in healthy individuals. Here, we perform a meta-analysis of nine datasets and focus on the …

The destruction or disruption of the body's own tissues by the immune system results from a
complex interaction of genetic and environmental factors. Inbred populations such as …

The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms
and genetic factors has been called autoimmune tautology, and indicates that they have a …

The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

Three related lines of evidence sustain the common origin for autoimmune diseases (ADs).
First, the clinical evidence corresponding to the kaleidoscope of autoimmunity, which is the …