The intermediate conductance Ca2+-activated K+ (IK) channel is distinguished from the
functionally related Ca2+-activated K+ channels of smaller and larger unitary conductance …

In human T-lymphocytes, the voltage-gated Kv1. 3 channel and the Ca (2+)-activated IKCa1
channel play an important role in Ca2+ signaling, activation, adhesion and migration and …

The antimycotic clotrimazole, a potent inhibitor of the intermediate-conductance calcium-
activated K+ channel, IKCa1, is in clinical trials for the treatment of sickle cell disease and …

Abstract The voltage-gated Kv1. 3 channel and the Ca 2+-activated IKCa1 K+ channel are
expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation …

During the last two decades since the identification and characterization of T cell potassium
channels great advances have been made in the understanding of the role of these …

This review discusses the Ca2+-activated K+ channels of intermediate conductance (IK
channels), and their historical discovery in erythrocytes, their classical biophysical …

We have used a structure-based design strategy to transform the polypeptide toxin
charybdotoxin, which blocks several voltage-gated and Ca 2+-activated K+ channels, into a …

The ion channels expressed by T lymphocytes play key roles in the control of the membrane
potential and calcium signaling, thereby affecting signal transduction pathways that lead to …

The intermediate conductance Ca 2+-activated K+ channel (IK Ca channel) encoded by K
Ca 3.1 is responsible for the control of proliferation and differentiation in various types of …

Human peripheral blood T lymphocytes possess two types of K+ channels: the voltage-
gated Kv1. 3 and the calcium-activated IKCa1 channels. The use of peptidyl inhibitors of …