The mechanisms by which inductive signals control the identity, proliferation and timing of
differentiation of progenitor cells in establishing spatial pattern in developing vertebrate …

The anterior and intermediate lobes of the pituitary gland derive from the surface ectoderm.
They provide a simple system to assess mechanisms of developmental identity established …

The medial hypothalamus is composed of nuclei of the tuberal hypothalamus, the
paraventricular nucleus of the anterior hypothalamus, and the neurohypophysis. Its …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The pituitary gland represents the endocrine core of the body, and its hormonal output
governs many key physiological processes. Because endocrine demands frequently …

Understanding the functional significance of the coordinate expression of specific
corepressors and DNA-binding transcription factors remains a critical question in …

Deficiencies in the homeobox transcription factors LHX4 and PROP1 cause pituitary
hormone deficiency in both humans and mice. Lhx4 and Prop1 mutants exhibit severe …

Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that
reflect the developmental history of POMC-expressing cells of the pituitary and …

Pituitary cell types arise in a temporally and spatially specific fashion, in response to
combinatorial actions of transcription factors induced by transient signaling gradients. The …

The pituitary gland has the primordial ability to dynamically adapt its cell composition to
changing hormonal needs of the organism throughout life. During the first weeks after birth …