Implementing pharmacogenomics in Europe: design and implementation strategy of the ubiquitous pharmacogenomics consortium

CH van der Wouden… - Clinical …, 2017 - Wiley Online Library
Despite scientific and clinical advances in the field of pharmacogenomics (PGx), application
into routine care remains limited. Opportunely, several implementation studies and …

Global pharmacogenomics within precision medicine: challenges and opportunities

MJ Chenoweth, KM Giacomini… - Clinical …, 2020 - Wiley Online Library
This commentary focuses on challenges to the widespread adoption of pharmacogenomics,
outlining issues that need to be addressed ranging from basic pharmacogenomics research …

User considerations in assessing pharmacogenomic tests and their clinical support tools

G Mukerjee, A Huston, B Kabakchiev… - NPJ genomic …, 2018 - nature.com
Pharmacogenomic (PGx) testing is gaining recognition from physicians, pharmacists and
patients as a tool for evidence-based medication management. However, seemingly similar …

Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries

K Blagec, JJ Swen, R Koopmann, KC Cheung… - PloS one, 2022 - journals.plos.org
Background The clinical implementation of pharmacogenomics (PGx) could be one of the
first milestones towards realizing personalized medicine in routine care. However, its …

Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics …

KS Just, M Steffens, JJ Swen, GP Patrinos… - European journal of …, 2017 - Springer
Purpose Due to the diversity within Europe, the implementation of pharmacogenomic testing
in clinical practice faces specific challenges. In the context of the European …

Pharmacogenomics in practice: A review and implementation guide

D Kabbani, R Akika, A Wahid, AK Daly… - Frontiers in …, 2023 - frontiersin.org
Considerable efforts have been exerted to implement Pharmacogenomics (PGx), the study
of interindividual variations in DNA sequence related to drug response, into routine clinical …

Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands

PCD Bank, JJ Swen, HJ Guchelaar - BMC medicine, 2019 - Springer
Abstract Background Pharmacogenetics (PGx) is currently implemented in hospitals to
optimize therapy with high-risk drugs. However, many drugs with dosing recommendations …

Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good

K Krebs, L Milani - Human genomics, 2019 - Springer
The field of pharmacogenomics (PGx) is gradually shifting from the reactive testing of single
genes toward the proactive testing of multiple genes to improve treatment outcomes, reduce …

Research directions in the clinical implementation of pharmacogenomics: an overview of US programs and projects

S Volpi, CJ Bult, RL Chisholm… - Clinical …, 2018 - Wiley Online Library
Response to a drug often differs widely among individual patients. This variability is
frequently observed not only with respect to effective responses but also with adverse drug …

The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics

PH O'Donnell, A Bush, J Spitz… - Clinical …, 2012 - Wiley Online Library
The paradigm of individualized drug therapy based on genetics is an ideal that is now
potentially possible. However, translation of pharmacogenomics into practice has …