Genetic Alzheimer's disease (AD) risk factors associate with reduced defensive amyloid β
plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to …

Alzheimer's disease (AD) patients display widespread mitochondrial defects. Brain
hypometabolism occurs alongside mitochondrial defects, and correlates well with cognitive …

The mammalian brain is extremely sensitive to alterations in cellular homeostasis as a result
of environmental or physiological insults. In particular, hypoxic/ischemic challenges (ie …

Abstract Development of effective treatments for Alzheimer's disease is complicated by the
poor understanding of its pathophysiology. Recent work suggests mitochondria may play a …

Several studies have demonstrated aberrations in the Electron Transport Complexes (ETC)
and Krebs (TCA) cycle in Alzheimer's disease (AD) brain. Optimal activity of these key …

While it is well established that stroke and cerebral hypoperfusion are risk factors for
Alzheimer′ s disease (AD), the molecular link between ischemia/hypoxia and amyloid …

Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Brain is the most energetically demanding organ of the body, and is thus vulnerable to even
modest decline in ATP generation. Multiple neurodegenerative diseases are associated with …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the
brain and blood, the molecular mechanisms behind these phenomena are unknown. Here …