[HTML][HTML] Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma
Angiosarcomas are rare malignant tumors of the endothelium, arising commonly from the
head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and …
head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and …
[HTML][HTML] Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma
Angiosarcomas are rare, clinically aggressive tumors with limited treatment options and a
dismal prognosis. We analyzed angiosarcomas from 68 patients, integrating information …
dismal prognosis. We analyzed angiosarcomas from 68 patients, integrating information …
[HTML][HTML] Genomic landscape of angiosarcoma: a targeted and immunotherapy biomarker analysis
Simple Summary Angiosarcomas (AS) are rare, highly aggressive sarcomas with limited
therapeutic options. Genomic sequencing techniques have identified recurrent genetic …
therapeutic options. Genomic sequencing techniques have identified recurrent genetic …
[HTML][HTML] Tumor immune microenvironment of cutaneous angiosarcoma with cancer testis antigens and the formation of tertiary lymphoid structures
T Magara, M Nakamura, Y Nojiri, M Yoshimitsu… - Frontiers in …, 2023 - frontiersin.org
Cutaneous angiosarcoma (CAS) is a highly malignant tumor with few effective treatments.
Although the indication for immune checkpoint inhibitors such as anti-PD-1 antibodies is …
Although the indication for immune checkpoint inhibitors such as anti-PD-1 antibodies is …
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research
CA Painter, E Jain, BN Tomson, M Dunphy… - Nature medicine, 2020 - nature.com
Despite rare cancers accounting for 25% of adult tumors, they are difficult to study due to the
low disease incidence and geographically dispersed patient populations, which has …
low disease incidence and geographically dispersed patient populations, which has …
[HTML][HTML] Clinical implications of systemic and local immune responses in human angiosarcoma
Angiosarcomas are a rare subtype of soft-tissue sarcomas which exhibit aggressive clinical
phenotypes with limited treatment options and poor outcomes. In this study, we investigated …
phenotypes with limited treatment options and poor outcomes. In this study, we investigated …
[HTML][HTML] The tumor immune microenvironmental analysis of 2,033 transcriptomes across 7 cancer types
Understanding the tumor microenvironment is important to efficiently identify appropriate
patients for immunotherapies in a variety of cancers. Here, we presented the tumor …
patients for immunotherapies in a variety of cancers. Here, we presented the tumor …
[HTML][HTML] ANXA1 as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis and experimental validation
Z Lin, M Wen, E Yu, X Lin, H Wang, J Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
The tumor microenvironment (TME) plays an important role in the growth and invasion of
glioma. This study aimed to analyze the composition of the immune microenvironment in …
glioma. This study aimed to analyze the composition of the immune microenvironment in …
Mapping the spatial proteome of head and neck tumors: key immune mediators and metabolic determinants in the tumor microenvironment
Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common cancer
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …
[HTML][HTML] Immunological and genomic analysis reveals clinically relevant distinctions between angiosarcoma subgroups
SG van Ravensteijn, YMH Versleijen-Jonkers… - Cancers, 2022 - mdpi.com
Simple Summary Angiosarcomas (AS) are rare and aggressive soft tissue sarcomas that can
be subdivided in de novo primary AS and secondary AS. They have a very poor prognosis …
be subdivided in de novo primary AS and secondary AS. They have a very poor prognosis …