Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …
interest in their use for other human diseases including cancer. However, the precise …
Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy
H Liu, L Huang, M Mao, J Ding, G Wu… - Advanced Functional …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) have shown great potential in drug delivery, disease diagnosis,
and treatment owing to their versatile native features and functions. RNA interference (RNAi) …
and treatment owing to their versatile native features and functions. RNA interference (RNAi) …
Selective encapsulation of therapeutic mRNA in engineered extracellular vesicles by DNA aptamer
S Zhang, Y Dong, Y Wang, W Sun, M Wei, L Yuan… - Nano Letters, 2021 - ACS Publications
Extracellular vesicles (EV)-based delivery of therapeutic mRNAs is challenged by the low
loading efficiency. In this study, we designed a DNA aptamer consisting of two parts: the …
loading efficiency. In this study, we designed a DNA aptamer consisting of two parts: the …
[HTML][HTML] Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy
The advent of novel therapeutics in recent years has urged the need for a safe, non-
immunogenic drug delivery vector capable of delivering therapeutic payloads specifically to …
immunogenic drug delivery vector capable of delivering therapeutic payloads specifically to …
Functional delivery of lipid-conjugated siRNA by extracellular vesicles
AJ O'Loughlin, I Mäger, OG de Jong, MA Varela… - Molecular Therapy, 2017 - cell.com
Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate
intercellular communication by transferring biomolecules, including proteins and RNA …
intercellular communication by transferring biomolecules, including proteins and RNA …
Equipping cancer cell membrane vesicles with functional DNA as a targeted vaccine for cancer immunotherapy
By inducing tumor-specific immune responses, tumor vaccines have recently aroused great
research interest. Herein, we design a targeted nanovaccine by equipping cell membrane …
research interest. Herein, we design a targeted nanovaccine by equipping cell membrane …
Engineered tumor-derived extracellular vesicles: potentials in cancer immunotherapy
A Taghikhani, F Farzaneh, F Sharifzad… - Frontiers in …, 2020 - frontiersin.org
Exosomes are nano vesicles from the larger family named Extracellular Vesicle (EV) s which
are released by various cells including tumor cells, mast cells, dendritic cells, B lymphocytes …
are released by various cells including tumor cells, mast cells, dendritic cells, B lymphocytes …
RNAi delivery by exosome-mimetic nanovesicles–Implications for targeting c-Myc in cancer
To develop RNA-based therapeutics, it is crucial to create delivery vectors that transport the
RNA molecule into the cell cytoplasm. Naturally released exosomes vesicles (also called …
RNA molecule into the cell cytoplasm. Naturally released exosomes vesicles (also called …
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation
X Zhou, Y Miao, Y Wang, S He, L Guo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) have been proved a promising small interfering RNA (siRNA)
delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) …
delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) …
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
S Stremersch, RE Vandenbroucke… - Journal of Controlled …, 2016 - Elsevier
Exosome-like vesicles (ELVs) play an important role in intercellular communication by acting
as natural carriers for biomolecule transfer between cells. This unique feature rationalizes …
as natural carriers for biomolecule transfer between cells. This unique feature rationalizes …
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