Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer

S Dong, X Liu, Y Bi, Y Wang, A Antony, DY Lee… - Nature …, 2023 - nature.com
The recent success of mRNA therapeutics against pathogenic infections has increased
interest in their use for other human diseases including cancer. However, the precise …

Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy

H Liu, L Huang, M Mao, J Ding, G Wu… - Advanced Functional …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) have shown great potential in drug delivery, disease diagnosis,
and treatment owing to their versatile native features and functions. RNA interference (RNAi) …

Selective encapsulation of therapeutic mRNA in engineered extracellular vesicles by DNA aptamer

S Zhang, Y Dong, Y Wang, W Sun, M Wei, L Yuan… - Nano Letters, 2021 - ACS Publications
Extracellular vesicles (EV)-based delivery of therapeutic mRNAs is challenged by the low
loading efficiency. In this study, we designed a DNA aptamer consisting of two parts: the …

[HTML][HTML] Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

MK Jayasinghe, M Pirisinu, Y Yang, B Peng… - Theranostics, 2022 - ncbi.nlm.nih.gov
The advent of novel therapeutics in recent years has urged the need for a safe, non-
immunogenic drug delivery vector capable of delivering therapeutic payloads specifically to …

Functional delivery of lipid-conjugated siRNA by extracellular vesicles

AJ O'Loughlin, I Mäger, OG de Jong, MA Varela… - Molecular Therapy, 2017 - cell.com
Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate
intercellular communication by transferring biomolecules, including proteins and RNA …

Equipping cancer cell membrane vesicles with functional DNA as a targeted vaccine for cancer immunotherapy

B Liu, Y Yang, Y Chao, Z Xiao, J Xu, C Wang… - Nano Letters, 2021 - ACS Publications
By inducing tumor-specific immune responses, tumor vaccines have recently aroused great
research interest. Herein, we design a targeted nanovaccine by equipping cell membrane …

Engineered tumor-derived extracellular vesicles: potentials in cancer immunotherapy

A Taghikhani, F Farzaneh, F Sharifzad… - Frontiers in …, 2020 - frontiersin.org
Exosomes are nano vesicles from the larger family named Extracellular Vesicle (EV) s which
are released by various cells including tumor cells, mast cells, dendritic cells, B lymphocytes …

RNAi delivery by exosome-mimetic nanovesicles–Implications for targeting c-Myc in cancer

TR Lunavat, SC Jang, L Nilsson, HT Park, G Repiska… - Biomaterials, 2016 - Elsevier
To develop RNA-based therapeutics, it is crucial to create delivery vectors that transport the
RNA molecule into the cell cytoplasm. Naturally released exosomes vesicles (also called …

Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation

X Zhou, Y Miao, Y Wang, S He, L Guo… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) have been proved a promising small interfering RNA (siRNA)
delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) …

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

S Stremersch, RE Vandenbroucke… - Journal of Controlled …, 2016 - Elsevier
Exosome-like vesicles (ELVs) play an important role in intercellular communication by acting
as natural carriers for biomolecule transfer between cells. This unique feature rationalizes …