Infections of people with complement deficiencies and patients who have undergone splenectomy
S Ram, LA Lewis, PA Rice - Clinical microbiology reviews, 2010 - Am Soc Microbiol
The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …
Under physiological conditions, activation of the fluid-phase components of complement is …
Infectious diseases associated with complement deficiencies
JE Figueroa, P Densen - Clinical microbiology reviews, 1991 - Am Soc Microbiol
The complement system consists of both plasma and membrane proteins. The former
influence the inflammatory response, immune modulation, and host defense. The latter are …
influence the inflammatory response, immune modulation, and host defense. The latter are …
Mannose‐binding lectin: targeting the microbial world for complement attack and opsonophagocytosis
DL Jack, NJ Klein, MW Turner - Immunological reviews, 2001 - Wiley Online Library
Mannose‐binding lectin (MBL) is an important constituent of the innate immune system. This
protein binds through multiple lectin domains to the repeating sugar arrays that decorate …
protein binds through multiple lectin domains to the repeating sugar arrays that decorate …
Mannan‐binding lectin and its role in innate immunity
DC Kilpatrick - Transfusion Medicine, 2002 - Wiley Online Library
Mannan‐binding lectin (MBL) is a plasma collectin (C‐type lectin with a collagen‐like
domain) and is considered an important component of innate immunity. Circulating MBL is …
domain) and is considered an important component of innate immunity. Circulating MBL is …
Clinical manifestations of mannan-binding lectin deficiency
S Thiel, PD Frederiksen, JC Jensenius - Molecular immunology, 2006 - Elsevier
Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the
ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More …
ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More …
Mannan binding lectin deficiency and concomitant immunodefects
J Aittoniemi, M Baer, E Soppi, T Vesikari… - Archives of disease in …, 1998 - adc.bmj.com
OBJECTIVE To determine the prevalence of a mannan binding lectin (MBL) deficiency in
children with increased susceptibility to infections and to investigate whether other …
children with increased susceptibility to infections and to investigate whether other …
Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system
M Cedzynski, J Szemraj, AST Świerzko… - Clinical & …, 2004 - academic.oup.com
Blood samples were collected over a 4-year period from 335 children (aged 1–16 years)
suffering from recurrent respiratory infections and 78 controls. The patients were subdivided …
suffering from recurrent respiratory infections and 78 controls. The patients were subdivided …
Complement deficiency and disease
BP Morgan, MJ Walport - Immunology today, 1991 - cell.com
Complement deficiency is associated with an increased prevalence of pyogenic infections
and immune complex disease. The spectrum of disease in deficient individuals depends on …
and immune complex disease. The spectrum of disease in deficient individuals depends on …
Complement: an overview for the clinician
JC Varela, S Tomlinson - Hematology/Oncology Clinics, 2015 - hemonc.theclinics.com
The complement system is a major component of the innate immune system and it provides
a powerful and effective mechanism to protect the host from pathogens. It was first described …
a powerful and effective mechanism to protect the host from pathogens. It was first described …
Impact of mannose-binding lectin on susceptibility to infectious diseases
DP Eisen, RM Minchinton - Clinical Infectious Diseases, 2003 - academic.oup.com
When the adaptive immune response is either immature or compromised, the innate
immune system constitutes the principle defense against infection. Mannose-binding lectin …
immune system constitutes the principle defense against infection. Mannose-binding lectin …