Higher-order chromatin structure is emerging as an important regulator of gene expression.
Although dynamic chromatin structures have been identified in the genome, the full scope of …

In mammals, chromatin organization undergoes drastic reprogramming after fertilization.
However, the three-dimensional structure of chromatin and its reprogramming in …

The three-dimensional structure of chromatin plays a crucial role in development and
disease, both of which are associated with transcriptional changes. However, given the …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

In multicellular organisms, transcription regulation is one of the central mechanisms
modelling lineage differentiation and cell-fate determination. Transcription requires dynamic …

Chromatin modifications are crucial for development, yet little is known about their dynamics
during differentiation. Hematopoiesis provides a well-defined model to study chromatin state …

Modified parental histones are segregated symmetrically to daughter DNA strands during
replication and can be inherited through mitosis. How this may sustain the epigenome and …

The establishment of the embryonic and trophoblast lineages is a developmental decision
underpinned by dramatic differences in the epigenetic landscape of the two compartments …