Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Cystic fibrosis (CF) remains the most common life-shortening hereditary disease in white
populations, with high morbidity and mortality related to chronic airway mucus obstruction …

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis
transmembrane conductance regulator (CFTR), an anion channel expressed in epithelial …

Treatment for cystic fibrosis (CF) has conventionally targeted downstream consequences of
the defect such as mucus plugging and infection. More recently, significant advances have …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or absent functional CFTR …

With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …

Since the 1989 discovery that mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene cause cystic fibrosis (CF), there has been substantial progress …

An improved understanding of the cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …

Cystic fibrosis (CF) is the most common genetic life‐shortening condition in Caucasians.
Despite being a multi‐organ disease, CF is classically diagnosed by symptoms of …

Cystic fibrosis is caused by dysfunction or deficiency of the cystic fibrosis transmembrane
conductance regulator (CFTR) protein, an epithelial chloride channel that has a key role in …