The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for
nociceptive modulation. However, the underlying neural pathway and the function of specific …

Pain chronicity involves unpleasant experience in both somatosensory and affective
aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However …

The medial prefrontal cortex (mPFC) is a brain region involved in the affective components
of pain and undergoes plasticity during the development of chronic pain. Dopamine (DA) is …

The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects
of pain. There is extensive evidence that chronic pain produces functional changes within …

Chronic pain can cause both hyperalgesia and anxiety symptoms. However, how the two
components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical …

The medial prefrontal cortex (mPFC) is implicated in processing sensory-discriminative and
affective pain. Nonetheless, the underlying mechanisms are poorly understood. Here we …

Neural circuits that determine the perception and modulation of pain remain poorly
understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective …

The mechanisms for acute pain regulation in the brain are not well understood. The
prefrontal cortex (PFC) provides top-down control of emotional processes, and it projects to …

Noxious stimuli are detected by peripheral nociceptors and then transmitted to higher CNS
centers, where they are perceived as an unpleasant sensation. The mechanisms that govern …

Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The
prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors. Recent …