Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Treatment of pain is one of the major challenges in clinical medicine. However, it is often
difficult to evaluate the effect of a treatment, as the many symptoms of the underlying …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

The increasing popularity of the mouse as a subject in basic science studies of pain can
largely be attributed to the development of transgenic 'knockout'technology in this species …

For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …

Nociception and pain is a large field of both neuroscience and medical research. Over time,
various tests and models were developed in rodents to provide tools for fundamental and …

Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli;
the results thus may not fully reflect the human pain phenotype. Alterations in physical and …

The current gap between basic science research and the development of new analgesics
presents a serious challenge for the future of pain medicine. This challenge is particularly …