The Alazami syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness
The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …
Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism
La and La-related proteins (LARPs) are characterized by a common RNA interaction
platform termed the La module. This structural hallmark allows LARPs to pervade various …
platform termed the La module. This structural hallmark allows LARPs to pervade various …
Novel compound heterozygous variants in the LARP7 gene in a patient with Alazami syndrome
S Dateki, T Kitajima, T Kihara, S Watanabe… - Human Genome …, 2018 - nature.com
The LARP7 gene encodes a chaperone protein of the noncoding RNA 75 K, and mutations
in this gene have been identified in patients with Alazami syndrome. Herein, we report …
in this gene have been identified in patients with Alazami syndrome. Herein, we report …
LARP7-mediated U6 snRNA modification ensures splicing fidelity and spermatogenesis in mice
X Wang, ZT Li, Y Yan, P Lin, W Tang, D Hasler… - Molecular cell, 2020 - cell.com
U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …
spliceosome, is heavily modified post-transcriptionally, with 2′-O-methylation being most …
The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …
SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing
S Subramania, LM Gagné, S Campagne… - Nucleic acids …, 2019 - academic.oup.com
Src associated in mitosis (SAM68) plays major roles in regulating RNA processing events,
such as alternative splicing and mRNA translation, implicated in several developmental …
such as alternative splicing and mRNA translation, implicated in several developmental …
AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors
Alternative splicing of pre-mRNAs significantly contributes to the complexity of gene
expression in higher organisms, but the regulation of the splice site selection remains …
expression in higher organisms, but the regulation of the splice site selection remains …
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are
frequently observed in lung adenocarcinoma (LUAD). We have previously shown that …
frequently observed in lung adenocarcinoma (LUAD). We have previously shown that …
STAU1 binding 3′ UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown
For a number of human genes that encode transcripts containing inverted repeat Alu
elements (IR Alu s) within their 3′ untranslated region (UTR), product mRNA is efficiently …
elements (IR Alu s) within their 3′ untranslated region (UTR), product mRNA is efficiently …
Argonaute binding within human nuclear RNA and its impact on alternative splicing
Y Chu, S Yokota, J Liu, A Kilikevicius, KC Johnson… - Rna, 2021 - rnajournal.cshlp.org
Mammalian RNA interference (RNAi) is often linked to the regulation of gene expression in
the cytoplasm. Synthetic RNAs, however, can also act through the RNAi pathway to regulate …
the cytoplasm. Synthetic RNAs, however, can also act through the RNAi pathway to regulate …