Purpose One of the most important risk factors for hereditary breast and ovarian cancer is
young age. We aim to report the frequency of pathogenic/likely pathogenic variants in breast …

Breast cancer, a worldwide leading cause of cancer in women, may occur in familial cases.
Germline mutations in BRCA1/2 genes are responsible for 15% of the familial cases. With …

PURPOSE The prevalence of germline pathogenic variants (PVs) in established breast
cancer predisposition genes in women in the general population over age 65 years is not …

Purpose Although breast cancer in young women accounts for< 10% of diagnoses annually,
tumors in young patients exhibit more aggressive characteristics and higher mortality rates …

Introduction: Approximately 5% of breast cancers are diagnosed in women 40 years of age
or younger. Known risk factors for young-onset breast cancer are few and can only account …

Background Breast cancer is the most common malignancy in women and thought to be
hereditary in 10% of patients. Recent next-generation sequencing studies have increased …

Genetic testing for germline mutations in breast cancer predisposition genes can potentially
identify individuals at a high risk of developing breast and/or ovarian cancer. There is a …

Objective The objective of the current study was to analyse the frequency and spectrum of
germline variant profiles and clinicopathological characteristics of breast cancer patients …

Because the contribution of genetic factors to the burden of breast cancer is not well
investigated in Iran, we aimed to examine the prevalence of mutations in breast cancer …

Introduction: International guidelines recommend genetic testing for women with familial
breast cancer at an expected prevalence of pathogenic germline variants (PVs) of at least …