[HTML][HTML] GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

S Talukdar, EJ Bae, T Imamura, H Morinaga, WQ Fan… - Cell, 2010 - cell.com
Summary Omega-3 fatty acids (ω-3 FAs), DHA and EPA, exert anti-inflammatory effects, but
the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor …

Diets containing α-linolenic (ω3) or oleic (ω9) fatty acids rescues obese mice from insulin resistance

V Oliveira, R Marinho, D Vitorino, GA Santos… - …, 2015 - academic.oup.com
Subclinical systemic inflammation is a hallmark of obesity and insulin resistance. The results
obtained from a number of experimental studies suggest that targeting different components …

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages

DS Im - European Journal of pharmacology, 2016 - Elsevier
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which are plentiful in fish oil, have been
known for decades to be beneficial functional nutrients in different disease states. GPR120 …

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

S Talukdar, JM Olefsky, O Osborn - Trends in pharmacological sciences, 2011 - cell.com
The past decade has seen great progress in the understanding of the molecular
pharmacology, physiological function and therapeutic potential of G-protein-coupled …

A novel anti-inflammatory role of GPR120 in intestinal epithelial cells

AN Anbazhagan, S Priyamvada… - … of Physiology-Cell …, 2016 - journals.physiology.org
GPR120 (free fatty acid receptor-4) is a G protein-coupled receptor for medium-and long-
chain unsaturated fatty acids, including ω-3 fatty acids. Recent studies have shown GPR120 …

Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells

K Mobraten, TM Haug, CR Kleiveland, T Lea - Lipids in health and disease, 2013 - Springer
Abstract Background Omega-3 PUFAs are known to have anti-inflammatory properties, and
different mechanisms are involved. GPR120 is a G-protein coupled receptor that has …

Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons

L Wellhauser, DD Belsham - Journal of neuroinflammation, 2014 - Springer
Background Overnutrition and the ensuing hypothalamic inflammation is a major
perpetuating factor in the development of metabolic diseases, such as obesity and diabetes …

Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor

M Suzuki, S Takaishi, M Nagasaki, Y Onozawa… - Journal of Biological …, 2013 - ASBMB
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids
(MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that …

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Y Yan, W Jiang, T Spinetti, A Tardivel, R Castillo… - Immunity, 2013 - cell.com
Summary Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety
of inflammatory human diseases, but the mechanisms remain poorly understood. Here we …

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

DY Oh, E Walenta, TE Akiyama, WS Lagakos… - Nature medicine, 2014 - nature.com
It is well known that the ω–3 fatty acids (ω–3-FAs; also known as n–3 fatty acids) can exert
potent anti-inflammatory effects,,,. Commonly consumed as fish products, dietary …