Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling

BD Medoff, Y Okamoto, P Leyton, M Weng… - American journal of …, 2009 - atsjournals.org
Obesity is associated with an increased incidence and severity of asthma, as well as other
lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory …

Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice

SA Shore, RD Terry, L Flynt, A Xu, C Hug - Journal of Allergy and Clinical …, 2006 - Elsevier
BACKGROUND: Epidemiologic data indicate an increased incidence of asthma in the
obese. OBJECTIVE: Because serum levels of the insulin-sensitizing and anti-inflammatory …

Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension

M Weng, MJ Raher, P Leyton, TP Combs… - American journal of …, 2011 - atsjournals.org
Remodeling of the pulmonary arteries is a common feature among the heterogeneous
disorders that cause pulmonary hypertension. In these disorders, the remodeled pulmonary …

Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease

R Summer, CA Fiack, Y Ikeda, K Sato… - … of Physiology-Lung …, 2009 - journals.physiology.org
Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum
and has anti-inflammatory and systemic vascular-protective properties. In this study, we …

Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway

L Zhu, X Chen, L Chong, L Kong, S Wen… - International …, 2019 - Elsevier
Adiponectin plays a role in asthma and obesity, but its effects and mechanism in obesity-
related asthma remain elusive. This study aimed to evaluate the effects of adiponectin on …

Adiponectin in asthma: implications for phenotyping

E Nigro, A Daniele, O Scudiero… - Current Protein and …, 2015 - ingentaconnect.com
Asthma is a heterogeneous inflammatory airway disease, which exhibits multiple
phenotypes, mainly defined by a combination of different clinical features. Asthma …

Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies

A Sood, SA Shore - Journal of allergy, 2013 - Wiley Online Library
Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and
resistin) or anti‐inflammatory (such as adiponectin). Effects of these adipokines on the lungs …

Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema

M Miller, A Pham, JY Cho… - American Journal of …, 2010 - journals.physiology.org
Adiponectin is a cytokine with both proinflammatory and anti-inflammatory properties that is
expressed in epithelial cells in the airway in chronic obstructive pulmonary disease …

Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice

AS Williams, DI Kasahara, NG Verbout, AV Fedulov… - PLoS …, 2012 - journals.plos.org
Adiponectin is an adipose derived hormone that declines in obesity. We have previously
shown that exogenous administration of adiponectin reduces allergic airways responses in …

Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease?

R de Lima Azambuja, LSE da Costa Santos Azambuja… - Lung, 2015 - Springer
Purpose The relationship between asthma and obesity is well established, although the
pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a …