Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling
BD Medoff, Y Okamoto, P Leyton, M Weng… - American journal of …, 2009 - atsjournals.org
Obesity is associated with an increased incidence and severity of asthma, as well as other
lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory …
lung disorders, such as pulmonary hypertension. Adiponectin (APN), an antiinflammatory …
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
BACKGROUND: Epidemiologic data indicate an increased incidence of asthma in the
obese. OBJECTIVE: Because serum levels of the insulin-sensitizing and anti-inflammatory …
obese. OBJECTIVE: Because serum levels of the insulin-sensitizing and anti-inflammatory …
Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension
M Weng, MJ Raher, P Leyton, TP Combs… - American journal of …, 2011 - atsjournals.org
Remodeling of the pulmonary arteries is a common feature among the heterogeneous
disorders that cause pulmonary hypertension. In these disorders, the remodeled pulmonary …
disorders that cause pulmonary hypertension. In these disorders, the remodeled pulmonary …
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease
Adiponectin (APN) is an adipocyte-derived factor that exists at high concentrations in serum
and has anti-inflammatory and systemic vascular-protective properties. In this study, we …
and has anti-inflammatory and systemic vascular-protective properties. In this study, we …
Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway
L Zhu, X Chen, L Chong, L Kong, S Wen… - International …, 2019 - Elsevier
Adiponectin plays a role in asthma and obesity, but its effects and mechanism in obesity-
related asthma remain elusive. This study aimed to evaluate the effects of adiponectin on …
related asthma remain elusive. This study aimed to evaluate the effects of adiponectin on …
Adiponectin in asthma: implications for phenotyping
Asthma is a heterogeneous inflammatory airway disease, which exhibits multiple
phenotypes, mainly defined by a combination of different clinical features. Asthma …
phenotypes, mainly defined by a combination of different clinical features. Asthma …
Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies
A Sood, SA Shore - Journal of allergy, 2013 - Wiley Online Library
Adipokines, factors produced by adipose tissue, may be proinflammatory (such as leptin and
resistin) or anti‐inflammatory (such as adiponectin). Effects of these adipokines on the lungs …
resistin) or anti‐inflammatory (such as adiponectin). Effects of these adipokines on the lungs …
Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema
M Miller, A Pham, JY Cho… - American Journal of …, 2010 - journals.physiology.org
Adiponectin is a cytokine with both proinflammatory and anti-inflammatory properties that is
expressed in epithelial cells in the airway in chronic obstructive pulmonary disease …
expressed in epithelial cells in the airway in chronic obstructive pulmonary disease …
Role of the Adiponectin Binding Protein, T-Cadherin (Cdh13), in Allergic Airways Responses in Mice
Adiponectin is an adipose derived hormone that declines in obesity. We have previously
shown that exogenous administration of adiponectin reduces allergic airways responses in …
shown that exogenous administration of adiponectin reduces allergic airways responses in …
Adiponectin in asthma and obesity: protective agent or risk factor for more severe disease?
R de Lima Azambuja, LSE da Costa Santos Azambuja… - Lung, 2015 - Springer
Purpose The relationship between asthma and obesity is well established, although the
pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a …
pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a …