Genetic testing has been extensively used to detect monogenic diseases such as cystic
fibrosis and Huntington disease. Illnesses with complex etiologies involving interactions …

Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but requires the construction and validation of clinical assays, interpretation …

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Polygenic risk scores (PRS) identify at-risk individuals for many common diseases. A
discussion of strengths and limitations is carried out in this review. PRS complement …

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

Polygenic inheritance is a non-Mendelian form of inheritance in which the risk of a trait,
disorder, or disease results from the combined contribution of variants from multiple genes …

Abstract Polygenic Risk Scores (PRS)(also known as polygenic scores, genetic risk scores
or polygenic indexes) capture genetic contributions of a multitude of markers that …

Background Polygenic risk scores (PRS) have been widely applied in research studies,
showing how population groups can be stratified into risk categories for many common …

Polygenic risk scores (PRSs) have become the standard for quantifying genetic liability in
the prediction of disease risks. PRSs are generally constructed as weighted sum scores of …

Disclaimer: This Points to Consider document is designed primarily as an educational
resource for clinical laboratory geneticists to help them provide quality clinical laboratory …