Although CD95L (also known as FasL) is still predominantly considered as a death ligand
that induces apoptosis in infected and transformed cells, substantial evidence indicate that it …

Endothelial cells lining new blood vessels that develop during inflammatory disorders or
cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent …

Apoptosis is a fundamental process that contributes to tissue homeostasis, immune
responses, and development. The receptor CD95, also called Fas, is a member of the tumor …

CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests
that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB …

Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune
response, and during development. CD95 (also known as Fas), a member of the tumor …

CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF)
superfamily. Although this transmembrane ligand has been mainly considered as a potent …

Since the ligand for the death factor CD95 (CD95L) was identified almost a decade ago, it
has been established that this molecule (CD95L, FasL, Apo-1L, CD178, TNFSF6, APT1LG1) …

Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …

Although the interaction of CD95L (also known as FasL) with its so-called death receptor
CD95 (Fas) induces an apoptotic signal responsible for the elimination of infected and …

The CD95 pathway is a critical apoptotic pathway used by immune cells to avoid cancer
development. CD95 ligand (CD95L) is found in several forms, as a cell membrane …