Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Modulating inflammatory cell responses to spinal cord injury: all in good time

AL Bowes, PK Yip - Journal of neurotrauma, 2014 - liebertpub.com
Spinal cord injury can have a range of debilitating effects, permanently impacting a patient's
quality of life. Initially thought to be an immune privileged site, the spinal cord is able to …

Modulating the immune response in spinal cord injury

A Ulndreaj, JCT Chio, CS Ahuja… - Expert review of …, 2016 - Taylor & Francis
In spinal cord injury (SCI), the primary mechanical trauma is followed by a secondary injury
cascade which expands the susceptible perilesional region and produces further permanent …

Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics

PG Popovich, TB Jones - Trends in pharmacological sciences, 2003 - cell.com
Recruitment of inflammatory leukocytes to the injured spinal cord is a physiological
response that is associated with the production of cytokines and proteinases that are …

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

X Sun, ZB Jones, X Chen, L Zhou, KF So… - Journal of …, 2016 - Springer
Spinal cord injury (SCI) is a devastating event that results in significant physical disabilities
for affected individuals. Apart from local injury within the spinal cord, SCI patients develop a …

Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury

FH Brennan, PG Popovich - Current opinion in neurology, 2018 - journals.lww.com
Emerging targets for reprograming the immune response to pro... : Current Opinion in Neurology
Emerging targets for reprograming the immune response to promote repair and recovery of …

The pathophysiological role of acute inflammation after spinal cord injury

S Okada - Inflammation and regeneration, 2016 - Springer
Traumatic spinal cord injury (SCI) causes irreparable severe motor and sensory dysfunction.
Mechanical trauma rapidly leads to blood-spinal cord barrier disruption, neural cell death …

Harmful and beneficial effects of inflammation after spinal cord injury: potential therapeutic implications

S David, R López-Vales, VW Yong - Handbook of clinical neurology, 2012 - Elsevier
Spinal cord injury (SCI) results in immediate damage followed by a secondary phase of
tissue damage that occurs over a period of several weeks. The mechanisms underlying this …