Drugs as instruments: a new framework for non-addictive psychoactive drug use

CP Müller, G Schumann - Behavioral and Brain Sciences, 2011 - cambridge.org
Most people who are regular consumers of psychoactive drugs are not drug addicts, nor will
they ever become addicts. In neurobiological theories, non-addictive drug consumption is …

Resolving the contradictions of addiction

GM Heyman - Behavioral and Brain sciences, 1996 - cambridge.org
Research findings on addiction are contradictory. According to biographical records and
widely used diagnostic manuals, addicts use drugs compulsively, meaning that drug use is …

Drug addiction and the memory systems of the brain

TW Robbins, KD Ersche… - Annals of the New York …, 2008 - Wiley Online Library
We review drug addiction from the perspective of the hypothesis that drugs of abuse interact
with distinct brain memory systems. We focus on emotional and procedural forms of memory …

Addiction as vulnerabilities in the decision process

AD Redish, S Jensen, A Johnson - Behavioral and brain sciences, 2008 - cambridge.org
In our target article, we proposed that addiction could be envisioned as misperformance of a
decision-making machinery described by two systems (deliberative and habit systems) …

Neuroleptics and operant behavior: the anhedonia hypothesis

RA Wise - Behavioral and brain sciences, 1982 - cambridge.org
Neuroleptic drugs disrupt the learning and performance of operant habits motivated by a
variety of positive reinforcers, including food, water, brain stimulation, intravenous opiates …

Non-pharmacological factors that determine drug use and addiction

SH Ahmed, A Badiani, KA Miczek, CP Müller - … & Biobehavioral Reviews, 2020 - Elsevier
Based on their pharmacological properties, psychoactive drugs are supposed to take control
of the natural reward system to finally drive compulsory drug seeking and consumption …

Animal models of psychoactive drug use and addiction–present problems and future needs for translational approaches

CP Müller - Behavioural Brain Research, 2018 - Elsevier
Drug addiction is a psychiatric disorder based on a dysfunction of the brain. It frequently
develops from a controlled drug consumption and drug instrumentalization (DI). Thereby, DI …

Neurobiological mechanisms in the transition from drug use to drug dependence

GF Koob, SH Ahmed, B Boutrel, SA Chen… - Neuroscience & …, 2004 - Elsevier
Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss
of control over intake, and impairment in social and occupational function. Animal models …

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

BJ Everitt, TW Robbins - Nature neuroscience, 2005 - nature.com
Drug addiction is increasingly viewed as the endpoint of a series of transitions from initial
drug use—when a drug is voluntarily taken because it has reinforcing, often hedonic, effects …

Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction

SH Ahmed - Neuroscience & Biobehavioral Reviews, 2010 - Elsevier
In standard drug self-administration settings, animals have no choice than drug use. As a
result, serious doubt exists about the interpretation of drug use in experimental animals. Is it …