Ligustrazine suppresses neuron apoptosis via the Bax/Bcl‐2 and caspase‐3 pathway in PC12 cells and in rats with vascular dementia
T Zhao, Y Fu, H Sun, X Liu - IUBMB life, 2018 - Wiley Online Library
The aim of this study was to examine the comprehensive neuroprotective mechanism of
ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular …
ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular …
Ligusticum chuanxiong exerts neuroprotection by promoting adult neurogenesis and inhibiting inflammation in the hippocampus of ME cerebral ischemia rats
M Wang, M Yao, J Liu, N Takagi, B Yang… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Cerebral ischemia, also known as stroke, can stimulate
the proliferation and migration of endogenous neural stem cells (NSC S) in subventricular …
the proliferation and migration of endogenous neural stem cells (NSC S) in subventricular …
Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells
The progressive death of neurons following exposure to high concentrations of glutamate
leads to loss of learning and memory and pathogenesis of neurodegenerative disorders …
leads to loss of learning and memory and pathogenesis of neurodegenerative disorders …
Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion
Z Feng, Y Lu, X Wu, P Zhao, J Li, B Peng, Z Qian… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Ligustilide (LIG), a main lipophilic component
of Danggui (Chinese Angelica root, Radix Angelica sinensis) which is a popular used herb …
of Danggui (Chinese Angelica root, Radix Angelica sinensis) which is a popular used herb …
Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties
YX Sun, Y Tang, AL Wu, T Liu, XL Dai… - Journal of Asian …, 2010 - Taylor & Francis
Our present study was conducted to investigate whether liquiritin (7-hydroxy-2-[4-[3, 4, 5-
trihydroxy-6-(hydroxymethyl) oxan-2-yl] oxyphenyl]-chroman-4-one, 1), an active component …
trihydroxy-6-(hydroxymethyl) oxan-2-yl] oxyphenyl]-chroman-4-one, 1), an active component …
Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic …
J Gu, J Chen, N Yang, X Hou, J Wang, X Tan… - Journal of …, 2016 - Elsevier
Abstract Ethnopharmacological relevance Combination of Ligusticum chuanxiong and
Radix Paeoniae (XS) is highly effective in the treatment for focal cerebral ischemic, but the …
Radix Paeoniae (XS) is highly effective in the treatment for focal cerebral ischemic, but the …
Liquiritigenin ameliorates memory and cognitive impairment through cholinergic and BDNF pathways in the mouse hippocampus
YH Ko, SH Kwon, SY Lee, CG Jang - Archives of pharmacal research, 2017 - Springer
Liquiritigenin (LQ), a flavonoid extracted from the radix of Glycyrrhiza, has anti-inflammatory
and neuroprotective properties. In this study, we evaluated the cognitive enhancing effects of …
and neuroprotective properties. In this study, we evaluated the cognitive enhancing effects of …
Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells
C Shi, F Wu, DT Yew, J Xu, Y Zhu - Apoptosis, 2010 - Springer
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba leaf extracts, has been
proposed to exert protective and trophic effects on neurons. However, mechanisms …
proposed to exert protective and trophic effects on neurons. However, mechanisms …
Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells
Y Nakatani, A Kobe, M Kuriya, Y Hiroki, T Yahagi… - European Journal of …, 2017 - Elsevier
Glycyrrhiza (the roots and rhizomes of licorice) has been used worldwide as both an herbal
nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains …
nutraceutical and herbal medicine. In addition, it is well known that Glycyrrhiza contains …
Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain
JJ Li, Q Zhu, YP Lu, P Zhao, ZB Feng, ZM Qian, L Zhu - Brain research, 2015 - Elsevier
Ligustilide (LIG) is a principal active ingredient of traditional Chinese medicine, Radix
Angelica sinensis, which has versatile pharmacological activities including neuroprotection …
Angelica sinensis, which has versatile pharmacological activities including neuroprotection …