New frontiers in selective human MAO-B inhibitors: miniperspective
S Carradori, R Silvestri - Journal of medicinal chemistry, 2015 - ACS Publications
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …
Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors
Monoamine oxidase (MAO) is an enzyme, present in mammals in two isoforms MAO-A and
MAO-B. These isoforms have a crucial role in neurotransmitters metabolism, representing an …
MAO-B. These isoforms have a crucial role in neurotransmitters metabolism, representing an …
[HTML][HTML] Inhibitors of MAO-A and MAO-B in psychiatry and neurology
JPM Finberg, JM Rabey - Frontiers in pharmacology, 2016 - frontiersin.org
Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and
neurological disorders respectively. Elucidation of the molecular structure of the active sites …
neurological disorders respectively. Elucidation of the molecular structure of the active sites …
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors
L Novaroli, A Daina, E Favre, J Bravo… - Journal of medicinal …, 2006 - ACS Publications
The impact of species-dependent differences between human and rat MAO B on inhibitor
screening was evidenced for two classes of compounds, coumarin and 5 H-indeno [1, 2-c] …
screening was evidenced for two classes of compounds, coumarin and 5 H-indeno [1, 2-c] …
Exploring new selective 3-benzylquinoxaline-based MAO-A inhibitors: design, synthesis, biological evaluation and docking studies
In this investigation, we searched for novel MAO-A inhibitors using a 3-benzylquinoxaline
scaffold based on our earlier findings. Series of N′-(3-benzylquinoxalin-2-yl) …
scaffold based on our earlier findings. Series of N′-(3-benzylquinoxalin-2-yl) …
8‐Substituted 3‐arylcoumarins as potent and selective MAO‐B inhibitors: Synthesis, pharmacological evaluation, and docking studies
D Viña, MJ Matos, G Ferino, E Cadoni… - …, 2012 - Wiley Online Library
Neurodegenerative disorders are becoming more prevalent given the increase in the aging
population. This has inspired active research in the development of new drugs that could …
population. This has inspired active research in the development of new drugs that could …
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
RKP Tripathi, SR Ayyannan - Medicinal research reviews, 2019 - Wiley Online Library
Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an
indispensable approach of molecular and mechanistic diversity for the discovery of …
indispensable approach of molecular and mechanistic diversity for the discovery of …
Selective MAO-B inhibitors: a lesson from natural products
S Carradori, M D'Ascenzio, P Chimenti, D Secci… - Molecular …, 2014 - Springer
Monoamine oxidases (MAOs) are mitochondrial bound enzymes, which catalyze the
oxidative deamination of monoamine neurotransmitters. Inside the brain, MAOs are present …
oxidative deamination of monoamine neurotransmitters. Inside the brain, MAOs are present …
Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …