During the last 20 years, molecular alterations have gained increasing significance in the
diagnosis and biological assessment of tumors. Gliomas represent the largest group of …

Novel insights into the pathogenesis of gliomas based on lar... : Current Opinion in
Neurology Novel insights into the pathogenesis of gliomas based on large-scale molecular …

Malignant brain tumours are one of the most relevant causes of morbidity and mortality
across a wide range of individuals. Malignant glioma is the most common intra axial tumor in …

Primary central nervous system (CNS) tumors constitute a small fraction of the overall
incidence of human cancer, but they represent a major source of cancer-related morbidity …

Diffuse gliomas are the most frequent brain tumor in adults. This group of brain neoplasms,
ranging from histologically benign to aggressive malignant forms, represents a challenge in …

The molecular biology of human glioma is a complex and fast-growing field in which basic
research needs to meet clinical expectations in terms of anti-tumor efficacy. Although much …

Technologic advances in oncogenomics, proteomics and functional genomic screens (such
as synthetic lethality) are providing mechanisms to rapidly identify the critical targets whose …

In addition to necrosis and apoptosis, the two forms of cell death that have been known for
many decades, other non-apoptotic forms of cell death have been discovered, many of …

A primary brain tumor glioblastoma is the most lethal of all cancers and remains an
extremely challenging disease. Apparent oncogenic signaling in glioblastoma is genetically …

Gliomas are a deadly primary malignant tumor of the central nervous system, with
glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM …