The mechanisms which lead to secondary brain damage following transient ischaemia are
incompletely defined. As discussed in this hypothesis article, the events which lead to such …

Ischemia is accompanied by mitochondrial dysfunction, as assessed by measurements of
mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial …

The mechanisms of reperfusion damage following focal cerebral ischemia are not known in
detail. Recent results, however, strongly suggest that reactive oxygen species (ROS) …

The pattern of selective vulnerability occurring after cerebral ischaemia is similar to that after
status epilepticus (Brierley, 1976; Corsellis and Meldrum 1976). In the hippocampus, the …

Brain ischaemia is a frequent and important sequel to brain injury. Areas of ischaemic brain
damage are an almost invariable finding at postmortem in patients who have sustained …

Resuscitation of the brain after a period of global ischemia is limited by two classes of
postischemic pathologies: hemodynamic disturbances which prevent the adequate re …

Ischaemic/hypoxic insults to the brain during surgery and anaesthesia can result in long-
term disability or death. Advances in resuscitation science encourage progress in clinical …

Following a hypoxic-ischemic insult, the collapse of ion gradients results in the inappropriate
release of excitatory neurotransmitters. Although excitatory amino acids such as glutamate …

It seems obvious to assume that the density of ischaemic brain damage, if incurred, is
related to both the severity and duration of cerebral ischaemia. As a corollary, only the …

A brief interruption of blood flow to the brain results in the selective loss of specific
subpopulations of neurons. Important advances have been made in recent years in defining …