Many recent studies have addressed the impact of gene patents and methods of gene
delivery on downstream research and innovation. The field of gene therapy has progressed …

Electroporation (EP) has been used in basic research for the past 25 years to aid in the
transfer of DNA into cells in vitro. EP in vivo enhances transfer of DNA vaccines and …

Introduction: Electroporation allows efficient delivery of DNA into cells and tissues, thereby
improving the expression of therapeutic or immunogenic proteins that are encoded by …

Twenty-five years after the publication of the first report on gene transfer in vitro in cultured
cells by the means of electric pulse delivery, reversible cell electroporation for gene transfer …

Simple plasmid DNA injection is a safe and feasible gene transfer method, but it confers low
transfection efficiency and transgene expression. This non-viral gene transfer method is …

Electroporation as a Method for the Efficient In Vivo Delivery of Therapeutic Genes Page 1 DNA
AND CELL BIOLOGY Volume 22, Number 12, 2003 © Mary Ann Liebert, Inc. P. 753 …

Successful gene therapy depends on the capability of delivering the desired gene or cDNA
to the tissue of interest, attaining the desired level of expression and, most importantly, the …

Nonviral gene transfer is markedly enhanced by the application of in vivo electroporation
(also denoted electrogene transfer or electrokinetic enhancement). This approach is safe …

As in vivo electroporation advances from the preclinical phase to clinical studies and
eventually to routine medical practice, the design of electroporation devices becomes …

The utilisation of nonviral gene delivery methods has been increasing st-eadily, however, a
drawback has been the relative low efficiency of gene transfer with naked DNA compared …