Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-
like episode, which is a severe neurological manifestation associated with subtypes of …

Objective Seizures constitute a frequent yet under‐described manifestation of mitochondrial
disorders (MDs). The aim of this study was to describe electroencephalography (EEG) …

Opinion statement While numerous treatments for mitochondrial disorders have been
suggested, relatively few have undergone controlled clinical trials. Treatment of these …

Background Epileptic seizures in patients with mitochondrial encephalomyopathy, lactic
acidosis, and stroke-like episodes (MELAS) are heterogeneous with no pathognomonic …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Mitochondria represent both the main source and target of reactive oxygen and nitrogen
species (RONS). In view of the large energy expenditure made by neurons during …

This narrative review focuses on the pathophysiology, diagnosis, and management of status
epilepticus in the context of primary mitochondrial disease. Epilepsy is common in …

Over the last 15 years, some 16 open and controlled clinical trials for potential treatments of
mitochondrial diseases have been reported or are in progress, and are summarized and …

Substantial evidence indicates that mitochondria are a major checkpoint in several
pathways leading to neuronal cell death, but discerning critical propagation stages from …

Seizures are often the key manifestation of neurological diseases caused by pathogenic
mutations in 169 of the genes that have so far been identified to affect mitochondrial …