Macrophages are the most abundant and one of the most critical cells of tumor immunity.
They provide a bridge between innate and adaptive immunity through releasing cytokines …

Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades.
However, a significant proportion of patients remain unresponsive, largely due to the …

The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Macrophages are a specialized class of innate immune cells with multifaceted roles in
modulation of the inflammatory response, homeostasis, and wound healing. While …

Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-
associated macrophages (TAMs) in the tumor microenvironment (TME) are composed of …

ABSTRACT M2-like tumor-associated macrophages promote tumor progression by
establishing an immunosuppressive tumor microenvironment. The phenotype and activity of …

Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Highlights•Single-cell sequencing reveals enormous macrophage complexity.•Strong
functional imprinting of tumor-associated macrophages by tumor microenvironment.• …

Cancer research in recent decades has highlighted the potential influence of the tumor
microenvironment on the progression and metastasis of most known cancer types. Within …