Keratinocytes regulate melanogenesis in a paracrine manner. Previous studies have shown
that melatonin can directly inhibit melanin production in the melanocytes. However, it is …

UVB exposure accelerates skin aging and pigmentation. Melatonin effectively regulates
tyrosinase (TYR) activity and aging. The purpose of this study was to determine the …

It remains unclear how the multifunctional indoleamine neurohormone, melatonin, alters
melanin production and melanocytes within intact human epidermis under physiologically …

Vitiligo is characterized by the development of white patches on the skin either due to the
loss of functional melanocytes or perturbations in the melanogenesis pathway. In the …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells;
therefore, search for factors regulating this pathway are strongly desired. Herein, we …

Melatonin is present in all living organisms where it displays a diversity of physiological
functions. Attenuation of melanogenesis by melatonin has been reported in some mammals …

When exposed to hostile environments such as radiation, physical injuries, chemicals,
pollution, and microorganisms, the skin requires protective chemical molecules and …

Melatonin, one of the evolutionarily most ancient, highly conserved and most pleiotropic
hormones still operative in man, couples complex tissue functions to defined changes in the …

Melatonin (N-acetyl-5-methoxytryptamine, MEL), its kynurenic (N 1-acetyl-N 2-formyl-5-
methoxykynurenine, AFMK) and indolic derivatives (6-hydroxymelatonin, 6 (OH) MEL and 5 …