Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

Abstract Development of therapeutics for genetically complex neurodegenerative diseases
such as sporadic amyotrophic lateral sclerosis (ALS) has largely been hampered by lack of …

The ability to reprogram adult somatic cells into pluripotent stem cells that can differentiate
into all three germ layers of the developing human has fundamentally changed the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease
caused by motor neuron loss, resulting in muscle wasting, paralysis and eventual death. A …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological
disease holds great promise; however, there is a lack of well-curated lines from a large array …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by
progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic …

Despite decades of research on amyotrophic lateral sclerosis (ALS), there is only one
approved drug, which minimally extends patient survival. Here, we investigated …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which a
greater understanding of early disease mechanisms is needed to reveal novel therapeutic …